中文名 | BAY 19-8004 |
英文名 | Lirimilast |
别名 | 化合物 T15766 |
英文别名 | LIRIMILAST Lirimilast BAY 19-8004 BAY 19-8004 - Lirimilast Urea,[2-(2,4-dichlorobenzoyl)-6-[(methylsulfonyl)oxy]-3-benzofuranyl]- UREA, N-[2-(2,4-DICHLOROBENZOYL)-6-[(METHYLSULFONYL)OXY]-3-BENZOFURANYL]- METHANESULFONIC ACID 2-(2,4-DICHLORO-BENZOYL)-3-UREIDO-BENZOFURAN-6-YL ESTER |
CAS | 329306-27-6 |
化学式 | C17H12Cl2N2O6S |
分子量 | 443.26 |
密度 | 1.619±0.06 g/cm3(Predicted) |
沸点 | 663.2±55.0 °C(Predicted) |
酸度系数 | 12.33±0.30(Predicted) |
存储条件 | 2-8°C,密封,干燥 |
体外研究 | In PDE4 assays Lirimilast (BAY 19-8004) is reported to be 5-fold more potent than Cilomilast and equipotent with CDP-840 using freshly prepared PDE4 from human PMNL. |
体内研究 | Since Lirimilast (BAY 19-8004) is orally active in the guinea-pig at 3 mg/kg and, more critically, in primates at 0.1 mg/kg/day it appears to have a good therapeutic ratio. In addition Lirimilast is found to be 3-fold more potent than Cilomilast when compared in a rat model of lung neutrophilic inflammation. |
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